aDepartment of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco 50740-521, Brazil bDepartment of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Pernambuco 50760-901, Brazil cDepartment of Chemistry, Federal University of Pará, Belém, Pará 66075-110, Brazil Received 19 June 2007; revised 26 December 2007; accepted 27 December 2007. Available online 6 January 2008.
Carapa guianensis (Meliaceae), known as Andiroba in Brazil, has been used by Amazon Rainforest indigenous communities for treatment of coughs, convulsions, skin diseases, arthritis, rheumatism, ear infections, to heal wounds and bruises and as an insect repellent. Carapa guianensis seed oil (SO) was evaluated for its acute and subacute toxicity (30 days) by the oral route in Wistar rats. In the acute toxicity test, SO (0.625–5.0 g/kg, n = 5/sex) did not produce any hazardous symptoms or deaths. The subacute treatment with SO (0.375, 0.75 and 1.5 g/kg, n = 10/group) failed to change body weight gain, food and water consumption. Hematological analysis showed no significant differences in any of the parameters examined. However, in the biochemical parameters, there was an increase in the alanine aminotransferase (ALT) serum level (29%) in the group SO 1.5 g/kg. In addition, absolute and relative liver weights were increased at the doses of 0.75 g/kg (23.4 and 19.1%) and 1.5 g/kg (18.7 and 33.1%). In conclusion, acute and subacute administration of Carapa guianensis seed oil did not produce toxic effects in male Wistar rats. However, the increase in the ALT serum level and in both absolute and relative liver weights may indicate a possible hepatic toxicity.
Nome: Evandro Ferreira Cidade: Rio Branco-Ac, Brazil Quem sou eu: Acreano, nascido em Rio Branco, Pesquisador do Inpa-Ac e do Parque Zoobotânico da UFAC. Mestrado em Botânica no Lehman College, New York, USA, e Ph.D. em Botânica Sistemática pela City University of New York (CUNY) & The New York Botanical Garden (NYBG).
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